ICPR 2012 - Mitosis detection contest

Mitosis Detection in Breast Cancer Histological Images

ICPR 2012 contest (International Conference on Pattern Recognition) - Tsukuba, Japan, November 11-15, 2012
An initiative of  IPAL UMI CNRS lab (I2R/A*STAR, UJF, UPMC), TRIBVN, Pitié-Salpêtrière Hospital and Ohio State University

(To participate to this contest, and to get access to the training data set, please send an email to Ludovic Roux, ludovic.roux@ipal.cnrs.fr)

Nottingham Grading System is an international grading system for breast cancer recommended by the World Health Organization. It is derived from the assessment of three morphological features: tubule formation, nuclear pleomorphism and mitotic count. Several studies on automatic tools to process digitized slides have been reported focusing mainly on nuclei or tubule detection. Mitosis detection is a challenging problem and has not been addressed well in the literature.

Mitotic count is an important parameter in breast cancer grading as it gives an evaluation of the agressiveness of the tumour. Detection of mitosis is a very challenging task since mitosis are small objects with a large variety of shape configurations. The four main phases of a mitosis are prophase, metaphase, anaphase and telophase. The shape of the nucleus is very different depending on the phase of the mitosis. On its last stage, the telophase, a mitosis has two distinct nuclei, but they are not yet full individual cells. A mitosis in telophase must be counted as a single mitosis, it should not be miscounted as two mitosis. Artefacts are also common and should not be confused with mitosis.

The competition consists in being able to tell what is the mitotic count on an image. Different types of images are provided. The contestants can take advantage of using the information of some of the spectral bands which may be more discriminating for the detection of mitosis, or to concentrate only on RGB images.

Map of the Participants

 

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